研究業績

Sensitization to macadamia 7S globulin amino-terminus with clinical relevance in Japanese children with macadamia nut allergy.

Ando T, Kitaura J, Maruyama N, Narita M, Miura K, Takasato Y, Nogami K, Nagao M, Okumura K, Ogawa H, Onishi H, Watanabe T, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Hasegawa S, Ohya Y, Yasudo H.

Allergol Int. 2022 Dec 2;S1323-8930(22)00130-7. doi: 10.1016/j.alit.2022.11.005.

A Pediatric Case of Wheat-Dependent, Exercise-Induced Anaphylaxis Solely Associated with High-Molecular-Weight Glutenin.

Watanabe C, Ando Y, Kumagai H, Miyamoto M, Fujita Y, Kato M, Nakayama M, Maruyama N, Yamagata Y, Yoshihara S.

Indian Journal of Pediatrics 2022 Sep;89(9):937. doi: 10.1007/s12098-022-04319-5.

Predictive value of 7S globulin-specific IgE in Japanese macadamia nut allergy patients.

Yasudo H, Ando T, Kitaura J, Maruyama N, Narita M, Natsume O, Uneoka K, Miura K, Morita Y, Kamei A, Okamoto Y, Shirakawa S, Kitabayashi T, Kurihara K, Nogami K, Takasato, Y, Nagao M, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Saito H, Hasegawa S, Ohya Y.

J Allergy Clin Immunol Prac. S2213-2198(22)00016-2 (2022)

Wheat α-gliadin and high-molecular-weight glutenin subunit accumulate in different storage compartments of transgenic soybean seed.

Matsuoka Y, Cabanos S, Maruyama N.

Transgenic Res. 31, 43-58 (2022).

Soybean proteins/peptides: A review on their importance, biosynthesis, vacuolar sorting, and accumulation in seeds.

Cabanos S, Matsuoka Y, Maruyama N.

Peptides 143:170598 (2021)

Components of plant-derived food allergens: Structure, diagnostics, and immunotherapy.

Maruyama N.

Allergol. Int. 70, 291-302 (2021)

Site-directed mutagenesis by biolistic transformation efficiently generates inheritable mutations in a targeted locus in soybean somatic embryos and transgene-free descendants in the T 1 generation.

Adachi K, Hirose A, Kanazashi Y, Hibara M, Hirata T, Mikami M, Endo M, Hirose S, Maruyama N, Ishimoto M, Yamada T.

Transgenic Res. 30, 77-89 (2021).

Simultaneous induction of mutant alleles of two allergenic genes in soybean by using site-directed mutagenesis.

Adachi K, Hirose A, Kanazashi Y, Adachi K, Hibara M, Itoh T, Mikami M, Endo M, Hirose S, Maruyama N, Abe J, Yamada T.

BMC Plant Biol. 20, 513 (2020)

Immunization with soybean storage protein containing amyloid-β 4-10 prevents spatial learning decline.

Kawarabayashi T, Terakawa T, Takahashi A, Hasegawa H, Narita S, Sato K, Nakamura T, Seino Y, Hirohata M, Baba N,

Ueda T, Harigaya Y, Kametani F, Maruyama N, Ishimoto M, St George-Hyslop P, Shoji M.

J Alzheimers Dis. 70(2):487-503 (2019).

Development of rice-seed-based oral allergy vaccines containing hypoallergenic Japanese cedar pollen allergen derivatives for immunotherapy.

Takaiwa F, Yang L, Takagi H, Maruyama N, Wakasa Y, Ozawa K, Hiroi T.

J Agric Food Chem. 67(47):13127-13138 (2019).

Ses i 1-specific IgE and sesame oral food challenge results.

Yanagida N, Ejiri Y, Takeishi D, Sato S, Maruyama N, Takahashi K, Nagakura KI, Ogura K, Asaumi T, Ebisawa M.

J Allergy Clin Immunol Pract., 7(6):2084-2086 (2019).

Structure of the post-translational protein translocation machinery of the ER membrane.

Wu X, Cabanos C, Rapoport TA.

Nature, 566; 136-139 (2019).

Gly m 5/Gly m 8 fusion component as a potential novel candidate molecule for diagnosing soybean allergy in Japanese children.

Maruyama N, Sato S, Cabanos C, Tanaka A, Ito K, Ebisawa M.

Clinical and Experimental Allergy, 48, 1726-1734 (2018).

Specific IgE for Fag e 3 predicts oral buckwheat food challenge test results and anaphylaxis: A pilot study.

Yanagida N, Sato S, Maruyama N, Takahashi K, Nagakura KI, Ogura K, Asaumi T, Ebisawa M.

Int Arch Allergy Immunol. 176(1):8-14 (2018).

Cloning, molecular analysis, and developmental expression of 3 oleosin cDNA isoforms in coconut (Cocos nucifera L.).

Vargas A, Cabanos C, Garcia R, Maruyama N, Tecson-Mendoza EM.

The Journal of Horticultural Science and Biotechnology, 93, 255-263 (2018).

A Molecular target for an alcohol chain-length cutoff.

Chung HW, Petersen EN, Cabanos C, Murphy KR, Pavel MA, Hansen AS, Ja WW, Hansen SB.

Journal of Molecular Biology, 431; 196-209 (2018).

A vacuolar sorting receptor-independent sorting mechanism for storage vacuoles in soybean seeds.

Maruyama N, Matsuoka Y, Yokoyama K, Takagi K, Yamada T, Hasegawa H, Terakawa T, Ishimoto M.

Scientific Reports 8, 1108 (2018).

A soluble fluorescent binding assay reveals PIP2 antagonism of TREK-1 channels.

Cabanos C, Wang M, Han X, Hansen SB.

Cell Reports, 20, 1287-1294 (2017).

Cloning, molecular analysis, and developmental expression of 3 oleosin cDNA isoforms in coconut (Cocos nucifera L.).

Vargas AG, Cabanos C, Garcia RN, Maruyama N, Tecson-Mendoza EM.

The Journal of Horticultural Science & Biotechnology (2017) Aug, 1-9.

Measurement of specific IgE antibodies to Ses i 1 improves the diagnosis of sesame allergy.

Maruyama N, Nakagawa T, Ito K, Cabanos C, Borres MP, Movérare R, Tanaka A, Sato S, Ebisawa M.

Clinical & Experimental Allergy 46, 163-171 (2016).

Deposition mode of transforming growth factor-beta expressed in transgenic rice seed.

Takaiwa F, Yang L, Maruyama N, Wakasa Y, Ozawa K.

Plant Cell Reports 35, 2461-2473 (2016).

Clinical utility of recombinant allergen components in diagnosing buckwheat allergy.

Maruyama N, Sato S, Yanagida N, Cabanos C, Ito K, Borres MP, Movérare R, Tanaka A, Ebisawa M.

The Journal of Allergy and Clinical Immunology: In Practice 4, 322-323 (2016).

Preliminary X-ray analysis of the binding domain of the soybean vacuolar sorting receptor complexed with a sorting determinant of a seed storage protein.

Maruyama N, Goshi T, Sugiyama S, Niiyama M, Adachi H, Takano K, Murakami S, Inoue T, Mori Y, Matsumura H, Mikami B

Acta Crystallogr F Struct Biol Commun 71, 132-135 (2015).

Knockdown of the 7S globulin subunits shifts distribution of nitrogen sources to the residual protein fraction in transgenic soybean seeds.

Yamada T, Mori Y, Yasue K, Maruyama N, Kitamura K, Abe J

Plant Cell Rep 33,1963-1976 (2014).

Stable accumulation of seed storage proteins containing vaccine peptides in transgenic soybean seeds.

Maruyama N, Fujiwara K, Yokoyama K, Cabanos C, Hasegawa H, Takagi K, Nishizawa K, Uki Y, Kawarabayashi T, Shouji M, Ishimoto M, Terakawa T

J Biosci Bioeng 118, 441-447 (2014).

Development of a novel transgenic rice with hypocholesterolemic activity via high-level accumulation of the α' subunit of soybean β-conglycinin.

Cabanos C, Kato N, Amari Y, Fujiwara K, Ohno T, Shimizu K, Goto T, Shimada M, Kuroda M, Masuda T, Takaiwa F, Utsumi S, Nagaoka S, Maruyama N

Transgenic Res 23, 609-620 (2014).

Differential expression and elution behavior of basic 7S globulin among cultivars under hot water treatment of soybean seeds.

Fujiwara K, Cabanos C, Toyota K, Kobayashi Y, Maruyama N

J Biosci Bioeng 117, 742-748 (2014).

Degradation of β-conglycinin β-homotrimer by papain: independent occurrence of limited and extensive proteolysis.

Shutov AD, Rudakova AS, Rudakov SV, Kakhovskaya IA, Schallau AA, Wilson KA, Maruyama N

Biosci Biotechnol Biochem 77, 2082-2086 (2013).

Purification, crystallization and preliminary crystallographic analysis of soybean mature glycinin A1bB2.

Prak K, Mikami B, Itoh T, Fukuda T, Maruyama N, Utsumi S

Acta Crystallogr Sect F Struct Biol Cryst Commun 69, :937-941 (2013).

Modification of solubility and heat-induced gelation of amaranth 11S globulin by protein engineering.

Carrazco-Peña L, Osuna-Castro JA, De León-Rodríguez A, Maruyama N, Toro-Vazquez JF, Morales-Rueda JA, Barba de la Rosa AP

J Agric Food Chem 61, 3509-3516 (2013).

Photoaffinity casting of a coumarin flag for rapid identification of ligand-binding sites within protein.

Morimoto S, Tomohiro T, Maruyama N, Hatanaka Y

Chem Commun (Camb) 49, 1811-1813 (2013).

High-level production of lactostatin, a hypocholesterolemic peptide, in transgenic rice using soybean A1aB1b as carrier.

Cabanos C, Ekyo A, Amari Y, Kato N, Kuroda M, Nagaoka S, Takaiwa F, Utsumi S, Maruyama N.

Transgenic Res 22, 621-629 (2013).

Crystal structure of a major seed storage protein, 11S proglobulin, from Amaranthus hypochondriacus: insight into its physico-chemical properties.

Tandang-Silvas MR, Cabanos CS, Carrazco Peña LD, De la Rosa AP, Osuna-Castro JA, Utsumi S, Mikami B, Maruyama N

Food Chem 135, 819-826 (2012).

Measurement of Ara h 1-, 2-, and 3-specific IgE antibodies is useful in diagnosis of peanut allergy in Japanese children.

Ebisawa M, Movérare R, Sato S, Maruyama N, Borres MP, Komata T

Pediatr Allergy Immunol 23, 573-581 (2012).

Limited proteolysis regulates massive degradation of glycinin, storage 11S globulin from soybean seeds: an in vitro model.

Shutov A, Rudakova A, Rudakov S, Kakhovskaya I, Schallau A, Maruyama N, Wilson K

J Plant Physiol 169, 1227-1233 (2012).

Molecular design of seed storage proteins for enhanced food physicochemical properties.

Tandang-Silvas MR, Tecson-Mendoza EM, Mikami B, Utsumi S, Maruyama N.

Annu Rev Food Sci Technol 2, 59-73 (2012).

Crystal structure of the major peanut allergen Ara h 1.

Cabanos C, Urabe H, Tandang-Silvas MR, Utsumi S, Mikami B, Maruyama N

Mol Immunol 49, 115-123 (2011).

Expression and purification of peanut oleosins in insect cells.

Cabanos C, Katayama H, Tanaka A, Utsumi S, Maruyama N

Protein J 30, 457-463 (2011).

The development of transgenic crops to improve human health by advanced utilization of seed storage proteins.

Maruyama N, Mikami B, Utsumi S

Biosci Biotechnol Biochem 75, 823-828 (2011). Review.

Crystallization and preliminary X-ray analysis of the major peanut allergen Ara h 1 core region.

Cabanos C, Urabe H, Masuda T, Tandang-Silvas MR, Utsumi S, Mikami B & Maruyama N

Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 1071-1073 (2010).

Soybean basic 7S globulin: subunit heterogeneity and molecular evolution.

Shutov AD, Prak K, Fukuda T, Rudakov SV, Rudakova AS, Tandang-Silvas MR, Fujiwara K, Mikami B, Utsumi S & Maruyama N

Biosci Biotechnol Biochem74,1631-1634 (2010).

Expression, purification and preliminary crystallization of amaranth 11S proglobulin seed storage protein from Amaranthus hypochondriacus L.

Tandang-Silvas MR, Carrazco-Pena L, Barba de la Rosa AP, Osuna-Castro JA, Utsumi S, Mikami B & Maruyama N

Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 919-922 (2010).

Development of transgenic rice containing a mutated beta subunit of soybean beta-conglycinin for enhanced phagocytosis-stimulating activity.

Motoyama T, Amari Y, Tandang-Silvas MR, Cabanos C, Kimura A, Yoshikawa M, Takaiwa F, Utsumi S & Maruyama N

Peptides 31, 1245-1250 (2010).

Expression, purification, cross-reactivity and homology modeling of peanut profilin.

Cabanos C, Tandang-Silvas MR, Odijk V, Brostedt P, Tanaka A, Utsumi S & Maruyama N

Protein Expr Purif 73, 36-45 (2010).

Conservation and divergence on plant seed 11S globulins based on crystal structures.

Tandang-Silvas MR, Fukuda T, Fukuda C, Prak K, Cabanos C, Kimura A, Itoh T, Mikami B, Utsumi S & Maruyama N

Biochim Biophys Acta 1804, 1432-1442 (2010).

Carbohydrate moieties contribute significantly to the physicochemical properties of french bean 7s globulin phaseolin.

Kimura A, Tandang-Silvas MR, Fukuda T, Cabanos C, Takegawa Y, Amano M, Nishimura S, Matsumura Y, Utsumi S & Maruyama N

J Agric Food Chem 58, 2923-2930 (2010).

Co-expression of alpha' and beta subunits of beta-conglycinin in rice seeds and its effect on the accumulation behavior of the expressed proteins.

Motoyama T, Okumoto Y, Tanisaka T, Utsumi S & Maruyama N

Transgenic Res19, 819-827 (2010).

Aggregation of proteins having Golgi apparatus determinant induces large globular structures derived from the endoplasmic reticulum in plant seed cells.

Maruyama N, Okuda E, Tatsuhara M & Utsumi S

FEBS Lett 582,1599-1606 (2008).

The C-terminal region of α′subunit of soybean β-conglycinin contains two types of vacuolar sorting determinants.

Nishizawa K, Maruyama N & Utsumi S

Plant Mol Biol 62, 111-125 (2006).

Multiple vacuolar sorting determinants sxist in soybean 11S globulin.

Maruyama,N., Loeng CM, Tatsuhara M, Sawada M, Ishimoto M & Utsumi S

Plant Cell18, 1253-1273 (2006).